Targeting of mutant NY-PR-1 in breast cancer using chimeric antigen receptor engineered T

Targeting of mutant NY-PR-1 in breast cancer using chimeric antigen receptor engineered T

Order #:
719365
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Language:
English (U.S.)
Order Type:          Assignment
Level:          
Subject:          CELLULAR BIOLOGY SHOULD BE DONE BY Alex
Order Topic:          Targeting of mutant NY-PR-1 in breast cancer using chimeric antigen receptor engineered T cells
Instruction: paraphrasing sentences

Targeting of mutant NY-PR-1 in breast cancer using chimeric antigen
receptor engineered T cells
3
Control animals will be injected IP route with a similar volume of PBS. This step is required to test
the toxicity of the therapeutic approach.
Quality Control Step
– All animal experiments will be conducted in accordance with accepted standards of animal care and
agreement with a protocol established with Ethics committee.
– Tumor growth will be monitored by Bioluminescence imaging.
– Dosing sites, injection volume and needle size should be carefully considered to minimize the
trauma.
– Function of Indium – labeled T cells is confirmed by their ability to produce serum concentration of
cytokines ( INF-γ , IL-6 and TNF-α ) using ELISA and by their ability to elicit destruction of
tumor using SPECT-CT imaging

 

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